Yes, the TRUE statement is:

Early and continuous use of fluoride can assist in remineralizing demineralized tooth structure

The other statements are FALSE because:

The first clinical evidence of tooth demineralization from low pH is a white spot (also called a white spot lesion) that appears with no breakthrough to the enamel surface.

During remineralization, tooth destruction from caries can be arrested. The minerals will be restored to the tooth's crystal structure. If remineralization occurs in the early stages, the white spot lesions can harden and become hypermineralized compared with the surrounding enamel.